Ductular Reaction in Total and Partial Biliary Obstruction in Experimental Settings

In this paper, the features of ductular reaction (DR) and remodeling biliary tract in experimental models are discussed total selective occlusion. It has been shown that intensity DR, as well shape, number, topography profiles following common bile duct occlusion (CBDO) closely related to duration obstruction. addition, formation new can occur by widening existing ducts/ductules a result cholangiocyte proliferation, hepatocyte transdifferentiation, and/or activation differentiation stem/progenitor cells. concluded DR induced CBDO consists components all types DRs, including I, II (A B), III, thus increasing interest further studies model. CBDO, consequent “preproliferative” “proliferative” phases developed parallel with cells transdifferentiation (the “para-proliferative” phase) should be distinguished. The dynamics these important consider for detailed classification DRs. During obstruction, full range characteristics not determined (mainly events proliferation fibrosis noted). However, great compensatory potential bed confirmed, reflected collaterals between congested noncongested ducts.